Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrol
نویسندگان
چکیده
منابع مشابه
Sirt1 activation by resveratrol is substrate sequence-selective
Sirtuins are protein deacetylases used as therapeutic targets. Pharmacological Sirt1 activation has been questioned since the in vitro activator resveratrol failed to stimulate deacetylation of several physiological substrates. We tested the influence of substrate sequence by analyzing resveratrol effects on Sirt1-dependent deacetylation of 6802 physiological acetylation sites using peptide mic...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2015
ISSN: 0890-9369,1549-5477
DOI: 10.1101/gad.265462.115